I started with FTM 2010 Platinum.
TreeSync works on my system with absolutely no problems.
I am doing manual treesync not automatic. Maybe because I am a compulsive control freak. Maybe because I don't want the program to automatically update stuff while I am trying to do something.
I am running Win7 x64 with a fast processor (i5-2500K), a lot of memory (16 GB) and a modestly fast hard drive.