Am delighted to see your well researched query regarding Spanish Jews here on the Orleans Parish/New Orleans query board.
The Spanish Inquisition was the chief reason for the formation of New Spain, in my opinion.
Do you belong to the Saudades Forum at Rootsweb? If you don't, you may want to check it out.
I am descended from a 'Gusman'from Andalucia, Spain... who married in 1755 in of all places, Nova Scotia and as if that weren't enough, he married a native of Port Royal.
I have backtracked and the Guzman/Gusman line were Spanish Jews before the Inquisition...but I have too large a gap to be able to research any further than c1733.
Good luck in your search.