Hi Mervyn
The Bottomleys entered my tree through marriage, so unfortunately i cannot say if Issac Bottomley is related to them.My Bottomleys came from the Shorditch/Bethnal Green Area. Jack Bottomley was born c1895 he married into my tree with Gertrude Letitia Neben.If you look him up on the 1901 census it will show his father and maybe he and Issac's father are brothers? You could contact the other member who answered my query prior to yourself.Her name is Stef and she would have a lot more info on the Bottomleys. Sorry i cannot help.
Regards Angela Smith