Tracey
At the time of her death [22 Jun 1849], she was living in the Spring Garden section of Philadelphia County (Philadelphia City) and I believe her residence would be now located under the Benjamin Franklin Parkway between North 20th and 21st, above North Vine Street. In relation to an existing structure, somewhere to the west of the Free Library of Philadelphia, not the Academy of Natural Sciences, which is on the south side of Vine Street.
This website may be helpful:
http://www.philageohistory.org/tiles/viewer/Pearl Street (Reeves) is shown as the first street north of Vine Street on maps on the 1858-1860 Philadelphia Atlas and subsequent year maps up till 1910 Philadelphia Atlas, after which it disappears from the area I previously indicated as being her residence. The 1875 Philadelphia Atlas does show the street with both names.
My ancestors were from that area 1840s to 1860s and maybe later. Possibly they shopped at the same stores!
Good luck,
Frank