There is a Wise ,VA and a Wise CO ,Virginia. Also the last name Shepard exists in the same county Zachariah owned land in, early in his life in Wilkes Co NC and this may be the daughter of James or John Shepard. The Shepards, Wells',Boggs' and other families all migrated with one another from 1780s-1805 and if you notice, all relocated to Wise County during this time period. I would begin searching Wilkes County birth records first.