Samuel Sample's wife was Hannah Copeland, daughter of Benjamin Copeland and Sarah Ann Boling. She was born abt 1747 in Isle of Wight VA and died 1 Nov 1791 in KY. She was NOT of Cherokee ancestry. Her sister Sarah married William Sample, but I have absolutely no info on him. I assume he is Samuel's brother.
Benjamin Copeland died abt 1754, at the age of 30, and his wife Sarah Ann remarried to a man named David Rolstone/Ralston in Augusta Co VA.
Andrew Sample had brothers Samuel Jr, Benjamin, and David.