Hello Penny,
Yes, your'e on the right road. It would appear that your ancestors meet with mine with Robert Pye (my 8x great grandfather) married to Elizabeth Plott, both born in Burbage, Wiltshire, England.
If I'm correct, their descendants are;
John Pye born 1663, Burbage, Wiltshire.
John Pye born 1682, Marlborough, Wiltshire, England.
Your John Pye born 1/1/1722, London, England (died 1755, Chatham County, GA) married to Elizabeth Brownfield.
Does this make sense? I look forward to hearing from.
Lucky hunting.
John.