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Hereditary Spherocytosis

Hereditary Spherocytosis

Posted: 22 May 2013 5:04PM GMT
Classification: Query
Edited: 22 May 2013 5:05PM GMT
There has been Hereditary Spherocytosis in the NC Pipes line known since 1906. I was wondering if any other Pipes lines either within NC or outside of NC have had this in their family. Would love to trace it back as far as possible. Obviously, earlier than this century, families would not have known what they were dealing with--but early deaths, severe anemias, early heart failure, jaundice conditions might be a clue within family lines. This is an autosomal dominant trait--it is not sex-linked. It has variable penetrence meaning that in any family, it can have different severity in any member of the family--ie a person can have it and live their entire life without severe problems, their siblings could die early from severe anemia and heart failure.

Re: Hereditary Spherocytosis

Posted: 8 Aug 2013 9:30AM GMT
Classification: Query
Surnames: Adams, Baker, Ballinger, Conlee, Durham, Ferguson, Garrison, Hogg, Johnson, McMinn, Nelson, Owen, Rogers, Ruffin, Shearin, Shipman, Thomas
Hereditary Spherocytosis is very heavily concentrated on my mom's dad's side of the family (William Newton "Newt" Adams, his parents being Leonard Clifford "LC" Adams and Roberta Pauline "Bert" Nelson). My grandpa was from Missouri, but it looks like further back around the 1700-1800s there could possibly be some North Carolina as well. If I've done my research right, some of those surnames may include:

Adams,
Baker,
Ballinger,
Conlee,
Durham,
Ferguson,
Garrison,
Hogg,
Johnson,
McMinn,
Owen,
Rogers,
Ruffin,
Shearin,
Shipman, and
Thomas.

From what I've read, HS is a genetic mutation that occurs in 1 in 2,000 people of Northern European descent. Both my maternal and paternal sides have their roots back to areas like England, Netherlands, France, Ireland, and Scotland, etc. The list above seems to include a fair number of Irish and Scottish folks.

Do any of these surnames mesh with ones you're tracing for HS?

Re: Hereditary Spherocytosis

Posted: 8 Aug 2013 10:55AM GMT
Classification: Query
Ferguson does I believe, but it really is back there--1700s. I'll have to reconfirm that it is on my father's side since it is back there. Haven't heard back on any of the other surname forums I've posted on. Most of my father's side is Scots Irish, Scots and Irish, along with English. And the obligate Cherokee, since they are from the mountain area of NC!
Thanks for your reply, Kathy S.
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