Amanda,

I believe Thomas had a brother named Josiah Murdaugh (1841-1861).
The children of Thomas Preacher Murdaugh and his first wife Susanna Victoria Bishop were as follows:

Florrie Ann Cynthia Murdaugh 1867 – 1953
Hezekiah Brown Murdaugh 1869 – 1948
Sheldonia Walton "Donie" Murdaugh 1870 – 1932
Charles Henry Charlie Murdaugh 1871 – 1934
Preacher Buist Murdaugh 1873 – 1931
William Clemmons Clem Murdaugh 1875 – 1938
Joannah A Murdaugh 1876 – 1877
Thomas Hampton Bub Murdaugh 1878 – 1948
Susannah Victoria Murdaugh 1879 – 1939

Thomas then married my great-great grandmother, Laura Jane Rentz and had the following children:

Marion Pauline Murdaugh 1881 – 1938
Mary Cumsee "Mamie" Murdaugh 1883 – 1967
Laura Catherine Murdaugh 1885 – 1889
Raymond Grafton Murdaugh 1888 – 1891
Frances Lewister "Lula" Murdaugh 1891 – 1967
Nina Ophelia Murdaugh 1894 – 1972
Beatrice Gertrude Murdaugh 1896 – 1961
Benjamin Franklin "Tank" Murdaugh 1898 – 1987
George Ebbie Murdaugh 1898 – 1979

I hope this helps!