In a 1737 Will of John James, Merchant of Liverpool, Lancashire, England, John says he will pay for his nephew's, JAMES LYTHGO's, education until he reaches age of 17. Thus far I have not found a James Lythgo, Lithgo, Lithgoe, Etc. who may be his nephew. Possible birth years are likely between about 1725-1735. Most of John James' relations are living in Lancashire in and near Liverpool.
Possible nephews would come from John James wife's family or his sisters. John's wife is Isabel Moon or Moone, while his own sisters are of the James surname.