My great grandmother was Taube/Toby/Tilly Laub Itzkowitz born abt 1866 in Iasi, married Hyman Silberman/Silverman, and came to NY in 1909. They lived mostly in Brooklyn and Bronx their whole lives. I think her father's name was Laib, and I think she had siblings Rosa, Mendel/Max and at least one more. She died in 1925, and is buried in Baron Hirsch Cemetery on Staten Island.
Her brother Mendel/Max Itzkowitz/Iskowitz (b. 1868) married Clara/Chaja/Ida Grossman, and settled in Brooklyn. The only thing I know about their sister Rosa is that she lived on Clinton St. in 1902, when her brother Mendel arrived, but I don't know if she was married then or what her name might have been.
I know nothing about any other siblings, but I believe there were some, or what became of the parents. I assume they remained in Romania.