I just read your post and I am curious. My father was Rev. Clyde E. Isgriggs from Potosi, Mo. His father was Les and mother was Edith Collins Fitts Isgriggs also from Potosi.
I have never heard your grandmothers name before or that spelling of Isgriggs in the Potosi area.
We believe that we are also from the William Isgrig line.
I would be interested in any information you might have that I do not.