I have, in my family, an Omega Isaacks, born about 1795 in North Carolina. He turns up in the 1850 Census in Chariton Co, Missouri, living next door to the Wise Family.
Love (Lovey) Isaacks (mother's last name: Wisdom), was the mother of my Great Grandmother, Nancy Catherine Wise (who married a Kahler); but I can not solidly connect Omega to the Wise family. (Nancy Catherine had a sister named Mary Omega Wise).
The talk of "North Carolina" in that book, is enticing.
There is always hope.