I take it that you're referring to the legend that James Gilliam Human, the founder of Humansville, was the son of a Cherokee mother. That legend has been debunked, most effectively by Charles Ward, see these two links:
http://archiver.rootsweb.ancestry.com/th/read/GILLIAM/2000-0...http://archiver.rootsweb.ancestry.com/th/read/GEORGE/2000-03...I hope that helps. I'm a descendant of James via his son William, for what it's worth.