Dear Yvonne, I realize your post is quite old, but want to reply anyway.
I believe there is a connection between my grandmother and Adrian Esqueda. My grandmother' sister, Mercedes, along with her husband and one daughter had a haute couture shop in Mexico City - all of them Esquedas. My grandmother was born in Atotonilco, but also had family in Aguascalientes, Guanajuato, Jalisco and Michoacan.
It is true that the first roots were from Spain's Basque regions. When I started looking for her family, I found that one single woman with two young children - a boy and a girl - had arrived Ellis Island from Europe, via a vessel from Austria.
I was told my grandmother, Juanita (or Maria Juana) was a beautiful lady with blond hair and blue eyes.
Hopefully you have some other information to share.