Before you spend your time looking in Roanoke, VA you might want to know a little Roanoke Valley History. The boys were in SC before there was a Roanoke in the mountains( not until 1881), and I doubt if they would call it by anything other than the name they grew up with. And it would appear Roanoke wasn't called anything until 1834.
There was also a Roanoke Township in Charlotte County. If Sellers "assumed" Roanoke meant VA and added the state by thought instead of fact then we might need to search around the Roanoke Island and Roanoke Rapids area of NC.
The History Of Roanoke
Known as the "Capital of the Blue Ridge," and a crossroads for commerce, the city of Roanoke's history began in the 1740s. Mark Evans and Tasker Tosh came from Pennslyvania and took up land near the salt licks where Indian and animal trails crossed in the center of the valley.
For generations, those salt marshes, or licks as they were called, had been a gathering place for buffalo, elk and deer, as well as for the Indians who hunted them. The salt marshes were to lend their name to the first village in the Roanoke Valley which started on the east-west path as Gainsborough in 1834; the town soon came to be known as Big Lick.
Roanoke County was formed out of Botetourt County in 1838, with a county population of approximately 5,000. There was an unknown, but certainly not a large, number of slaves in the area. The town of Salem became the county seat and boasted a population of about 200, with Big Lick numbering about 50 residents. The even smaller community of Vinton was to the east of Big Lick connected by a narrow brick road.
The railroad came to the valley in 1852, but missed Big Lick. So the little Town moved to the tracks, taking its name with it. The original town became Old Lick. In 1874, the new center was chartered as the town of Big Lick.
Seven years later, with the coming of the Shenandoah Valley Railroad, Big Lick was renamed Roanoke for the river and the county. Roanoke was derived from the Indian word "Rawrenock," a name for the shell beads worn by the Indians and used as trade goods.