Sherri, I'm pretty sure your John Anthony was a brother of my great-grandfather, James B. McDonough (1853-1900). They, and their siblings, Charles A. (1850-1924) and Jane (1847-1944), were born in Allegheny City, PA, to Charles Augustine McDonough and Mary Ann King.
It's circumstantial, but my John A. McD lived in Venango County and was born in 1844. I didn't know that his middle name was Anthony, but it's not surprising because he had an Uncle Anthony.
Get in touch--I'd be glad to share.