At least one family in Mckeesport associated with George Washington did a DNA study and their results came out that they were related to Native Americans in South Florida.
There has been a long standing connection between the old families of South Florida and Pittsburgh including stories out of Sarasota that General Grant's son Frederick Dent Grant was married into the family of Potter Palmer who was related to the Webb family of Spanish Point.
Even thought the first guests who visited Spanish Point were registered from Pittsburgh, the historians are very firm that there can't be any connection to Pittsburgh and Spanish Point.
The Heinz History Center begs to differ. The Grant and Dent families were originally from the Greater Pittsburgh area and some of the Grants are buried with the Bakewell and Croghan families at Allegheny Cemetery.
William Croghan was a close friend of General Churchill of Fort Churchill and brother to General Churchill's assistant Col Gorge Croghan. William Croghan married Lucy Clark who was the sister of William Clark of the Lewis and Clark Expedition out of Pittsburgh in 1803. They are buried with the Bakewells and Grants at Allegheny Cemetery.
Dr David de Leon was General Robert E Lee's personal doctor during the Civil War. He is related to the Myers family of Fort Myers in Lee County Florida. Actually there are more then several groups of families that were connected to West Point Commander General Robert E Lee before the Civil War who had forts named after them.
They are the Hays family of Ft Hays Kansas. The Sedgwick family of Ft Sedgwick CO. The Sill family of Ft Sill OK. The Churchill family of Ft Churchill NV and the Myers family of Ft Myers in Lee County Florida.
The EZest to find is the Hays family of Ft Hays. They are all buried with General Alexander Hays at Allegheny Cemetery in Pittsburgh. The Sill family is buried next to the Lewis and Clark cemetery lot at Versailles Cemetery. The Sills were related to a Kennedy family who are buried in the next lot over.
I believe these are the Kennedys connected to Lt Robert E Lee's wedding at Arlington VA to Mary Anna Randolph Custis in June of 1831. The wedding list states Smith Lee, Robert Lee's brother, was Best Man and cousin Lt John P Kennedy as being in the wedding party.
The Custis and Calvert families were well known Catholics connected to the Catholic Calvert family out of Baltimore. They in turn were connected to Catholic Gov of MD Thomas Sim Lee who was a cousin of Robert E Lee.
This brings us to Catholic Whiskey Maker Basil Hayden who lead a group of Catholic families from Frederick MD to Nelson County KY. They in turn lead to Whiskey Maker Jim Beam and the Dillinger Whiskey Company of Henry Clay Frick in Pittsburgh.
It was Robert E Lee's father who had his headquarters in McKeesport during the Pittsburgh Whiskey Rebellion of 1794.