Samuel Woodson Wren was married to Mary Elizabeth Simmons, daughter of Elisha Simmons and Sarah "Sallie" Winston. Sarah Winston was the daughter of John Winston and Sybylla Mosby. Sybylla Mosby was the sister of Mary "Polly" Mosby who married John W. Grant. Mary Mosby is the mother of Mary "Polly" Grant who was Samuel Woodson Wren's mother. So Samuel Woodson Wren and his wife were cousins. Their grandmother's were sisters.