I am also researching Alfred Owens, whose first wife was Agnes James. His second wife was Elizabeth and they lived in Drew County in 1850. They had a son named Newton, so I feel sure this is the same family you mentioned. I found Alfred and Elizabeth and their family living in Jefferson County by 1860 and found a daughter of Alfred's married by 1860. She married William Sanders and they were living in Jefferson County in the 1860 and 1870 censuses.
I'm looking for more information on the Owens family. My husband descends from Agnes James Owens' brother, George James.