Using Microsoft's new map site, I've pinned 298 (the corner of the Times Building) & 420 Holmes Avenue (just past the intersection with Lincoln St). It looks like the 300 block is now parking lot between them.
http://tinyurl.com/fcz73As downtown expanded, little was spared in the northwestern direction from the square unless it was a large church or other large building. Now that area is mostly banks and city offices.