On the certificate George Brett is her nephew. There are several births for George Brett's in Waterford but only 1 old enough to be a identified - I assume you would need to be of age?
George Brett died Waterford July-Sept 1850 born 1899.
George Brett marriage 1925 Jan-March, Waterford
Wyse Institute, just bits and pieces on wiki-pedia and other websites. The Wyse family were very well off owning large amounts of land and buildings including in the town of Waterford. Sounds like they had to sell most of it off.
Originally there was a convent and a school donated by the Wyse family, at one point part of the convent was used by the Poor Law Union. My guess is that either the convent became a catholic hospital in the years of Anastatia's death as many other buildings do. There were also big houses that could easily have been turned into hospitals and named for the Wyse family. Thomas Wyse 1791-1862www.landedestates.ie
has some information about the Wyse
One of the town properties was in the Parish of Trinity Without.
The Waterford Library might be a good resource, look through their records under 'local studies'.www.waterfordcountylibrary.ie
I think I probably wrote about the 1911 Census where Anastatia Brett 41 is listed as an inmate. When I look further they are all women, yes that would be normal at that time in any institution but these women are from all over Ireland not just Waterford. I wonder if it isn't a convent? This house housed many women and all are single and RC but the house was considered a private dwelling in the census and the head of the family is listed as Mary A. Loughlin. I think that would discount a poor house, asylum or similar institution.